Myostatin cas 901758-09-6 Polypeptide Supplements with Skeletal Muscle Regeneration
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Product Name | GDF 8Â Powder 1mg/vial Pharmaceutical Raw Materials High purity GDF-8(myostatin) |
 |  |
Packing | 1box/10vials,1mg/vial |
CAS No | 901758-09-6 |
Molecular Formula | C221H366N72O67S |
Application | Pharmaceutical raw materials |
purity | > 99.0% |
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Background: GDF-8/Myostatin:
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Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.
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GDF 8Â / Myostatin Structure and mechanism of action:
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.
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Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
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GDF 8Â / Myostatin Application:
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Myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
tibody. Should this product contain a precipitate we recommend microcentrifugation be.
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GDF 8Â / Myostatin COA:
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Item | Specification | Result |
Appearance | White powder | Complies |
Identification | Positive | Complies |
Assay | 99.0% min | 99. 3% |
Loss on Drying | 6.0%max. | 4.80% |
Mass Balance | 95.0~105.0% | Complies |
Acetate Content (HPIC) | 12.0%max. | 10.80% |
Peptide Content (N%) | 80.0%min. | 88.00% |
Amino Acid Composition | 10% of theoretical | Complies |
Single Impurity (HPLC) | 1.0%max. | 0.85% |
Peptide List:
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Name | Specification |
Follistatin 344 | 1mg/Vial |
Follistatin 315 | 1mg/Vial |
 |  |
 |  |
DSIP | 2mg/Vial |
Selank | 5mg/Vial |
Oxytocin | 2mg/Vial |
AOD-9604 | 2mg/Vial |
ACE 031 | 1mg/Vial |
Epitalon | 10mg/Vial |
MGF | 2mg/Vial |
MGF | 5mg/Vial |
PEG-MGF | 2mg/Vial |
CJC-1295 with DAC | 2mg/Vial |
CJC-1295 without DAC | 2mg/Vial |
PT-141 | 10mg/Vial |
MT-1 | 10mg/Vial |
MT-2 | 10mg/Vial |
GHRP-2 | 5mg/Vial |
GHRP-2 | 10mg/Vial |
GHRP-6 | 5mg/Vial |
GHRP-6 | 10mg/Vial |
Ipamorelin | 2mg/Vial |
Ipamorelin | 5mg/Vial |
Hexarelin | 2mg/Vial |
Sermorelin | 2mg/Vial |
Oxytocin | 2mg/Vial |
TB500 | 2mg/Vial |
TB500 | 5mg/Vial |
Pentadecapeptide BPC 157 | 2mg/vial |
 |  |
 |  |
Tesamorelin | 2mg/Vial |
Triptorelin | 2mg/Vial |
Gonadorelin | 2mg/Vial |
Gonadorelin | 10mg/Vial |
Myostatin cas 901758-09-6 Polypeptide Supplements with Skeletal Muscle Regeneration
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Quick View:
Â
Product Name | GDF 8Â Powder 1mg/vial Pharmaceutical Raw Materials High purity GDF-8(myostatin) |
 |  |
Packing | 1box/10vials,1mg/vial |
CAS No | 901758-09-6 |
Molecular Formula | C221H366N72O67S |
Application | Pharmaceutical raw materials |
purity | > 99.0% |
Â
Background: GDF-8/Myostatin:
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Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and -9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.
Â
GDF 8Â / Myostatin Structure and mechanism of action:
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.
Â
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
Â
GDF 8Â / Myostatin Application:
Â
Myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
tibody. Should this product contain a precipitate we recommend microcentrifugation be.
Â
GDF 8Â / Myostatin COA:
Â
Item | Specification | Result |
Appearance | White powder | Complies |
Identification | Positive | Complies |
Assay | 99.0% min | 99. 3% |
Loss on Drying | 6.0%max. | 4.80% |
Mass Balance | 95.0~105.0% | Complies |
Acetate Content (HPIC) | 12.0%max. | 10.80% |
Peptide Content (N%) | 80.0%min. | 88.00% |
Amino Acid Composition | 10% of theoretical | Complies |
Single Impurity (HPLC) | 1.0%max. | 0.85% |
Peptide List:
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Name | Specification |
Follistatin 344 | 1mg/Vial |
Follistatin 315 | 1mg/Vial |
 |  |
 |  |
DSIP | 2mg/Vial |
Selank | 5mg/Vial |
Oxytocin | 2mg/Vial |
AOD-9604 | 2mg/Vial |
ACE 031 | 1mg/Vial |
Epitalon | 10mg/Vial |
MGF | 2mg/Vial |
MGF | 5mg/Vial |
PEG-MGF | 2mg/Vial |
CJC-1295 with DAC | 2mg/Vial |
CJC-1295 without DAC | 2mg/Vial |
PT-141 | 10mg/Vial |
MT-1 | 10mg/Vial |
MT-2 | 10mg/Vial |
GHRP-2 | 5mg/Vial |
GHRP-2 | 10mg/Vial |
GHRP-6 | 5mg/Vial |
GHRP-6 | 10mg/Vial |
Ipamorelin | 2mg/Vial |
Ipamorelin | 5mg/Vial |
Hexarelin | 2mg/Vial |
Sermorelin | 2mg/Vial |
Oxytocin | 2mg/Vial |
TB500 | 2mg/Vial |
TB500 | 5mg/Vial |
Pentadecapeptide BPC 157 | 2mg/vial |
 |  |
 |  |
Tesamorelin | 2mg/Vial |
Triptorelin | 2mg/Vial |
Gonadorelin | 2mg/Vial |
Gonadorelin | 10mg/Vial |
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